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The influence of congo red on the cell wall and (1-3)-beta-D-glucan microfibril biogenesis in Saccharomyces cerevisiae

Lesions of dopamine nigral neurons not only result in depression-like behavior (in the substantia nigra pars compacta) but also lead to a cascade of functional modifications on the activity of basal ganglia circuits, with the dysregulation of the glutamate system.12,13 This pathophysiological mechanism is also shared with Parkinson's disease, with the destabilization of the brain reward mechanism being linked to an increased risk of DE relapse.14 Note, the higher frequency of cardiovascular disorders than in other patients is also associated with the decrease in the activity of GDH, the glutamate-metabolizing enzyme

While a previous report showed that hemozoin is rapidly ingested by human monocytes and exclusively localized in normally acidified phagolysosomes (Schwarzer et al, 2001), our findings suggest that hemozoin can perturb lysosomal membranes

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